StressCovidV1, Main, Exploration, bibRecord, 000B35

Life-Course Socioeconomic Position and Hippocampal Atrophy in a Prospective Cohort of Older Adults

Identifieur interne : 000B35 ( Main/Exploration ); précédent : 000B34; suivant : 000B36

Life-Course Socioeconomic Position and Hippocampal Atrophy in a Prospective Cohort of Older Adults

Auteurs : Martine Elbejjani [Canada] ; Rebecca Fuhrer [Canada] ; Michal Abrahamowicz [Canada] ; Bernard Mazoyer [France] ; Fabrice Crivello [France] ; Christophe Tzourio [France] ; Carole Dufouil [France]

Source :

Psychosomatic Medicine [ 0033-3174 ] ; 2016.

RBID : Hal:hal-01382527

English descriptors

mix :
- hippocampal atrophy, life course, older cohort, socioeconomic position.

Abstract

Objective: Low socioeconomic position (SEP) has been linked to an increased risk of dementia and cognitive decline. However, little is known about the association between SEP and morphologic brain changes in older age. This study examines the relationships between indicators of life-course SEP with both hippocampal volume (HcV) and HcV loss in a population-based cohort of 1328 older adults aged 65 to 80 years.Methods: Multivariable linear regression models were used to estimate the associations of SEP with baseline HcV and the annual rate of HcV atrophy according to three life-course conceptual models: the sensitive/critical periods model (which explored SEP in specific periods: in childhood [using parental education], early adulthood [based on participants' education], and midlife [based on participants' socioprofessional group]); the accumulation-of-risk model (life-course cumulative SEP), and the social mobility model (life-course SEP trajectories).Results: Participants with lower midlife SEP had smaller HcV (-0.08 cm3; 95% confidence interval, -0.15 to -0.01) and 0.17% (95% confidence interval, 0.04%-0.30%) faster hippocampal atrophy than participants with higher midlife SEP. Childhood and early adulthood SEPs were not related to hippocampal measures. The accumulation-of-risk and the social mobility models revealed that the accumulation of socioeconomic disadvantage and declining socioeconomic trajectories were related to faster hippocampal atrophy.Conclusions: In this cohort of older adults, lower socioprofessional attainment in midlife and disadvantageous life-course socioeconomic position were associated with faster hippocampal atrophy, a cerebral change linked to cognitive disorders. Results support the hypothesized links between socioenvironmental exposures related to stress and/or cognitive enrichment and brain/cognitive reserve capacities.

Url:

https://hal.archives-ouvertes.fr/hal-01382527

DOI: 10.1097/PSY.0000000000000365

Affiliations:

Links toward previous steps (curation, corpus...)

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Le document en format XML

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            </address>
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        <tutelles><tutelle active="#struct-300016" type="direct"><org type="institution" xml:id="struct-300016" status="VALID">          <orgName>Commissariat à l'énergie atomique et aux énergies alternatives</orgName>
          <orgName type="acronym">CEA</orgName>
          <desc>            <address>              <addrLine>Centre de SaclayCentre de GrenobleCentre de Cadaracheetc</addrLine>
              <country key="FR"></country>
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            <ref type="url">http://www.cea.fr/</ref>
          </desc>
        </org>
</tutelle>
<tutelle active="#struct-244085" type="direct"><org type="laboratory" xml:id="struct-244085" status="VALID">          <orgName>Institut des Maladies Neurodégénératives [Bordeaux]</orgName>
          <orgName type="acronym">IMN</orgName>
          <desc>            <address>              <addrLine>Bât. 3b 1er étage 146 Rue Léo Saignat 33076 Bordeaux </addrLine>
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          <desc>            <address>              <addrLine>35, place Pey Berland - 33076 Bordeaux</addrLine>
              <country key="FR"></country>
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            <ref type="url">http://www.u-bordeaux.fr/</ref>
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          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://www.cnrs.fr/</ref>
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</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Bordeaux</settlement>
<region type="region" nuts="2">Nouvelle-Aquitaine</region>
<region type="old region" nuts="2">Aquitaine</region>
</placeName>
<orgName type="university">Université de Bordeaux</orgName>
</affiliation>
</author>
<author><name sortKey="Crivello, Fabrice" sort="Crivello, Fabrice" uniqKey="Crivello F" first="Fabrice" last="Crivello">Fabrice Crivello</name>
<affiliation wicri:level="1"><hal:affiliation type="researchteam" xml:id="struct-555874" status="VALID">          <orgName>Groupe d'imagerie neurofonctionnelle</orgName>
          <orgName type="acronym">GIN</orgName>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://gin.cnrs.fr</ref>
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            <relation active="#struct-244085" type="direct"></relation>
            <relation active="#struct-259761" type="indirect"></relation>
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        <tutelles><tutelle active="#struct-300016" type="direct"><org type="institution" xml:id="struct-300016" status="VALID">          <orgName>Commissariat à l'énergie atomique et aux énergies alternatives</orgName>
          <orgName type="acronym">CEA</orgName>
          <desc>            <address>              <addrLine>Centre de SaclayCentre de GrenobleCentre de Cadaracheetc</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.cea.fr/</ref>
          </desc>
        </org>
</tutelle>
<tutelle active="#struct-244085" type="direct"><org type="laboratory" xml:id="struct-244085" status="VALID">          <orgName>Institut des Maladies Neurodégénératives [Bordeaux]</orgName>
          <orgName type="acronym">IMN</orgName>
          <desc>            <address>              <addrLine>Bât. 3b 1er étage 146 Rue Léo Saignat 33076 Bordeaux </addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://imn-bordeaux.org/</ref>
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<tutelle active="#struct-259761" type="indirect"><org type="institution" xml:id="struct-259761" status="VALID">          <orgName>Université de Bordeaux</orgName>
          <orgName type="acronym">UB</orgName>
          <desc>            <address>              <addrLine>35, place Pey Berland - 33076 Bordeaux</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.u-bordeaux.fr/</ref>
          </desc>
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</tutelle>
<tutelle name="UMR5293" active="#struct-441569" type="indirect"><org type="institution" xml:id="struct-441569" status="VALID">          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://www.cnrs.fr/</ref>
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<country>France</country>
<placeName><settlement type="city">Bordeaux</settlement>
<region type="region" nuts="2">Nouvelle-Aquitaine</region>
<region type="old region" nuts="2">Aquitaine</region>
</placeName>
<orgName type="university">Université de Bordeaux</orgName>
</affiliation>
</author>
<author><name sortKey="Tzourio, Christophe" sort="Tzourio, Christophe" uniqKey="Tzourio C" first="Christophe" last="Tzourio">Christophe Tzourio</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-55677" status="VALID">          <orgName>Epidémiologie et Biostatistique [Bordeaux]</orgName>
          <desc>            <address>              <addrLine>146, rue Léo-Saignat 33076 Bordeaux</addrLine>
              <country key="FR"></country>
            </address>
          </desc>
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        <tutelles><tutelle active="#struct-91134" type="direct"><org type="institution" xml:id="struct-91134" status="OLD">          <orgName>Université Bordeaux Segalen - Bordeaux 2</orgName>
          <desc>            <address>              <addrLine>146 rue Léo Saignat - 33076 Bordeaux cedex</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.univ-bordeauxsegalen.fr/</ref>
          </desc>
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<tutelle active="#struct-302259" type="direct"><org type="institution" xml:id="struct-302259" status="VALID">          <orgName>Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)</orgName>
          <desc>            <address>              <country key="FR"></country>
            </address>
          </desc>
        </org>
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<tutelle name="U897" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID">          <idno type="IdRef">026388278</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>            <address>              <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Dufouil, Carole" sort="Dufouil, Carole" uniqKey="Dufouil C" first="Carole" last="Dufouil">Carole Dufouil</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-55677" status="VALID">          <orgName>Epidémiologie et Biostatistique [Bordeaux]</orgName>
          <desc>            <address>              <addrLine>146, rue Léo-Saignat 33076 Bordeaux</addrLine>
              <country key="FR"></country>
            </address>
          </desc>
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        <tutelles><tutelle active="#struct-91134" type="direct"><org type="institution" xml:id="struct-91134" status="OLD">          <orgName>Université Bordeaux Segalen - Bordeaux 2</orgName>
          <desc>            <address>              <addrLine>146 rue Léo Saignat - 33076 Bordeaux cedex</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.univ-bordeauxsegalen.fr/</ref>
          </desc>
        </org>
</tutelle>
<tutelle active="#struct-302259" type="direct"><org type="institution" xml:id="struct-302259" status="VALID">          <orgName>Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)</orgName>
          <desc>            <address>              <country key="FR"></country>
            </address>
          </desc>
        </org>
</tutelle>
<tutelle name="U897" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID">          <idno type="IdRef">026388278</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>            <address>              <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
</analytic>
<idno type="DOI">10.1097/PSY.0000000000000365</idno>
<series><title level="j">Psychosomatic Medicine</title>
<idno type="ISSN">0033-3174</idno>
<imprint><date type="datePub">2016</date>
</imprint>
</series>
</biblStruct>
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</fileDesc>
<profileDesc><textClass><keywords scheme="mix" xml:lang="en"><term> hippocampal atrophy</term>
<term> life course</term>
<term> older cohort</term>
<term>socioeconomic position</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">              <p>Objective: Low socioeconomic position (SEP) has been linked to an increased risk of dementia and cognitive decline. However, little is known about the association between SEP and morphologic brain changes in older age. This study examines the relationships between indicators of life-course SEP with both hippocampal volume (HcV) and HcV loss in a population-based cohort of 1328 older adults aged 65 to 80 years.Methods: Multivariable linear regression models were used to estimate the associations of SEP with baseline HcV and the annual rate of HcV atrophy according to three life-course conceptual models: the sensitive/critical periods model (which explored SEP in specific periods: in childhood [using parental education], early adulthood [based on participants' education], and midlife [based on participants' socioprofessional group]); the accumulation-of-risk model (life-course cumulative SEP), and the social mobility model (life-course SEP trajectories).Results: Participants with lower midlife SEP had smaller HcV (-0.08 cm3; 95% confidence interval, -0.15 to -0.01) and 0.17% (95% confidence interval, 0.04%-0.30%) faster hippocampal atrophy than participants with higher midlife SEP. Childhood and early adulthood SEPs were not related to hippocampal measures. The accumulation-of-risk and the social mobility models revealed that the accumulation of socioeconomic disadvantage and declining socioeconomic trajectories were related to faster hippocampal atrophy.Conclusions: In this cohort of older adults, lower socioprofessional attainment in midlife and disadvantageous life-course socioeconomic position were associated with faster hippocampal atrophy, a cerebral change linked to cognitive disorders. Results support the hypothesized links between socioenvironmental exposures related to stress and/or cognitive enrichment and brain/cognitive reserve capacities.</p>
            </div>
</front>
</TEI>
<affiliations><list><country><li>Canada</li>
<li>France</li>
</country>
<region><li>Aquitaine</li>
<li>Nouvelle-Aquitaine</li>
<li>Québec</li>
</region>
<settlement><li>Bordeaux</li>
<li>Montréal</li>
</settlement>
<orgName><li>Université McGill</li>
<li>Université de Bordeaux</li>
</orgName>
</list>
<tree><country name="Canada"><region name="Québec"><name sortKey="Elbejjani, Martine" sort="Elbejjani, Martine" uniqKey="Elbejjani M" first="Martine" last="Elbejjani">Martine Elbejjani</name>
</region>
<name sortKey="Abrahamowicz, Michal" sort="Abrahamowicz, Michal" uniqKey="Abrahamowicz M" first="Michal" last="Abrahamowicz">Michal Abrahamowicz</name>
<name sortKey="Fuhrer, Rebecca" sort="Fuhrer, Rebecca" uniqKey="Fuhrer R" first="Rebecca" last="Fuhrer">Rebecca Fuhrer</name>
</country>
<country name="France"><region name="Nouvelle-Aquitaine"><name sortKey="Mazoyer, Bernard" sort="Mazoyer, Bernard" uniqKey="Mazoyer B" first="Bernard" last="Mazoyer">Bernard Mazoyer</name>
</region>
<name sortKey="Crivello, Fabrice" sort="Crivello, Fabrice" uniqKey="Crivello F" first="Fabrice" last="Crivello">Fabrice Crivello</name>
<name sortKey="Dufouil, Carole" sort="Dufouil, Carole" uniqKey="Dufouil C" first="Carole" last="Dufouil">Carole Dufouil</name>
<name sortKey="Tzourio, Christophe" sort="Tzourio, Christophe" uniqKey="Tzourio C" first="Christophe" last="Tzourio">Christophe Tzourio</name>
</country>
</tree>
</affiliations>
</record>

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Life-Course Socioeconomic Position and Hippocampal Atrophy in a Prospective Cohort of Older Adults

Life-Course Socioeconomic Position and Hippocampal Atrophy in a Prospective Cohort of Older Adults

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